Substituted 10-heterocyclicaminoalkyl-9,10-dihydroanthracenes

ABSTRACT

10-Aminoalkyl-9,10-dihydroanthracenes wherein the nucleus is substituted by halogen, lower alkyl, trifluoromethyl, lower alkylthio, lower alkylsulfonyl or N,N-dimethylsulfamyl and the amino group may be mono or dialkyl substituted as well as a monocyclic heterocyclic amino moiety are tranquilizers. Corresponding 9-lower alkyl or 9-phenyl derivatives also have utility as antidepressants. Compounds are generally prepared by reaction of a 10-bromoalkyl-anthracene with an appropriate amine followed by reduction to the 9,10-dihydroanthracene. 9-Substituted-10-aminoalkyl-9,10-dihydroanthracenes which are not benzo ring substituted have antidepressant activity with no tranquilizing activity. These compounds are generally prepared by alkylation of the 9,10-dihydroanthracene with an aminoalkyl halide.

United States Patent Craig et al.

SUBSTITUTED l0-HETEROCYCLlCAMlNOALKYL-Q,10- DIHYDROANTHRACENES Inventors: Paul N. Craig, Ambler; Charles L.

Zirkle. Berwyn, both of Pa Assignee: SmithKline Corporation,

Philadelphia, Pa.

Filed: June 28, 1973 Apple No: 374,745

Related U.S. Application Data Division of Ser. No. 121,544, March 5, l97l, Pat. No 3,766,183, which is a division of Ser. No. 742,l7l, July 3, I968, Pat No, 3,622,630, which is a continuation-impart of Ser. No. 63l,584, April l8, I967, abandoned. which is a continuation-impart of Ser. No 526.975, Feb l4, i966, abandoned.

U.S. Cl. 260/293.62; 260/293.62; 260/326.8; 260/326.82; 260/326.84

Int. Cl C07d 29/36 Field of Search 260/293.62, 3268, 326.83, 260/326.84, 326, 82

References Cited UNITED STATES PATENTS 3/[967 Engelhardt 260/556 July 22, 1975 FOREIGN PATENTS OR APPLICATIONS 618,034 2/1949 United Kingdom 2236]] [Cl/I962 Austria Primary Examiner-G. Thomas Todd Attorney, Agent, or Firm-Richard D. Foggio; William H. Edgerton [57] ABSTRACT l0-Aminoalkyl-9,lO-dihydroanthracenes wherein the nucleus is substituted by halogen, lower alkyl, trifluoromethyl, lower alkylthio, lower alkylsulfonyl or N,N-dimethylsulfamyl and the amino group may be mono or dialkyl substituted as well as a monocyclic heterocyclic amino moiety are tranquilizers. Corresponding 9-lower alkyl or 9-phenyl derivatives also have utility as antidepressants. Compounds are generally prepared by reaction of a lO-bromoalkylanthracene with an appropriate amine followed by re duction to the 9,l0-dihydroanthracene. 9-Substituted-lO-aminoalkyl9.lO-dihydroanthracenes which are not benzo ring substituted have antidepressant activity with no tranquilizing activityv These compounds are generally prepared by alkylation of the 9.10-dihydroanthracene with an aminoalkyl halidev 4 Claims, No Drawings l SUBSTITUTED l O-HETEROCYCLICAMlNOALKYL-9,10- DIHYDROANTHRACENES This is a division of application Ser. No. 12] ,544 filed Mar. 5, 1971, now US. Pat. No. 3,766,l83, dated Oct. 16, 1973, which is a division of application Ser. No. 742,l7l filed July 3, 1968, now US. Pat. No. 3,622,630, dated Nov. 23, l971, which is a continuation-inpart of abandoned Ser. No. 63l,584, Apr. 18, I967, which in turn is a continuation-in-part of abandoned application Ser. No. 526,975, Feb. 14, I966.

This invention relates to novel substituted lamihoalkyl-9,lO-dihydroanthracenes which have useful pharmacodynamic properties. More specifically the novel products of this invention effect the central nervous system and have utility as tranquilizers. The tranquilizing activity is demonstrated in standard pharmacological test procedures employed in characterizing chlorpromazine and trifluoperazine atroral dosages in rats, mice and monkeys approximately equivalent to the latter agents.

The novel l0-aminoalkyl-9,IO-dihydroanthracenes of this invention are represented by the following general structural formula:

when:

R represents hydrogen, lower alkyl, such as methyl or ethyl, or phenyl;

Y represents halogen having an atomic weight of less than 80, preferably chlorine, lower alkyl such as methyl, trifluoromethyl, lower alkylthio such as methylthio, lower alkylsulfonyl such as methylsulfonyl or N,N-dim ethylsulfamyl; t

piperazinyl,N'-(w-hydroxy-lower-alkyl)-N-piperazinyl,

N'-(w-hydroxy-alkoxy-lower-alkyl);N-piperazinyl, or N'-(w-acetoxy-lower alkyl)-N-piperazinyl,,

Advantageous compounds of this invention are represented by the following formula:

R l O! i" ca csui -z RMUIA I when:

R and R, represent hydrogen or methyl; and Z represents monomethylamino, dimethylamino, N- piperidinyl, N'-methyl-N-piperazinyl, N'-(w-hydroxye- 10-( 3 dimethylaminopropyl)-2-trifluoromethyl-9,l0-

dihydroanthracene and 9-methyll 0-( 3- dimethylaminopropyl)-2-trifluoromethyl-9, l0- dihydroanthracene.

Compounds of formulas l and [I above wherein R is lower alkyl or phenyl, in addition to having tranquilizing activity, also have utility as antidepressants. The antidepressant activity is demonstrated in standard pharmacological test procedures employed in characterizing imipramine and amitryptyline at oral dosages in mice and rats approximately equivalent to the latter agents.

By the terms lower alkyl or alkoxy where used herein alone or in combination with other terms, groups having from I to 4, preferably l to 2 carbon atoms are indicated.

This invention also includes stable, pharmaceutically acceptable, acid addition salts of the above defined bases formed with nontoxic organic and inorganic acids. Such salts are easily prepared by methods known to the art. The base is reacted with either the calculated amount of organic or inorganic acid in aqueous miscible, solvent such as acetone or ethanol, with isolation of the salt by concentration and cooling or an excess of the acid in aqueous immiscible solvent, such as ethyl ether or chloroform, with the desired salt separating directly. Exemplary of such organic salts are those with maleic, fumaric, benzoic, ascorbic, pamoic, succinic, bismethylenesalicylic, methanesulfonic, ethanedisulfonic, acetic, propionic, tartaric, salicylic, citric, gluconic, lactic, malic, mandelic, cinnamic, citraconic, aspartic, stearic, palmitic, itaconic, glycolic, paminobenzoic, glutamic, benzene sulfonic and theophylline acetic acids as well as with the 8- chlorotheophylline and 8-bromotheophylline. Exem plary of such'inorganic salts are those with hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, and

nitric acids. These salts may also be prepared by the classical method of double decomposition of appropriate salts which is well known to the art.

The l0-aminoalkyl-9,lO-dihydroanthracenes of this invention are prepared by one of several routes depending on the nuclear (Y) substitutent and the presence of a 9-allcyl or phenyl group. When the 9-position is unsubstituted (R=H) the products are obtained advantageously via the fully aromatic anthracenes which are prepared as shown in the following synthetic scheme illustrated by way of example for Z represented by dimethylamino:

in which Y and A are as defined in Formula I and X is halogen. preferably chlorine.

According to the above procedure, the substituted anthrone is reacted with a methoxyalkyl magnesium halide to give the lO-methoxyalkyl-l-hydroxy-9,l0- dihydroanthracenes. Advantagcously the reaction is carried out in an inert organic solvent such as an ether, for example diethyl ether, dioxane or. preferably tetra hydrofuran at a temperature of from about 0C. to room or ambient temperature for a period of about 3 to 24 hours. Removal of the solvent and treatment of the residue with water and/or an ammonium salt solu tion separates the lO-methoxyalkyl derivative. '1 he lat ter is treated with concentrated (48%) hydrobromic acid to give simultaneous dehydration of the l()* hydroxy group and cleavage of the methyl ether linkage. The resulting lO-bromoalkylanthracenes are treated with a di-loweralkylamine as shown above or ammonia. a mono-loweralkylamine, pyrrolidine, piperidine, N-lower alkyl-piperazine or N-(w-acetoxy-lower alkyl)-piperazine to give the corresponding l0- aminoalkylanthracenes of Formula Ill. The latter useful intermediates are reduced to give the 9.10- dihydroanthracene products of this invention with phosphorus and hydrogen iodide or with hydrogen and copper chromite catalyst when Y is trifluoromethyl.

Hydrolysis of the N'-acetoxyalkyl-N-piperazinyl products thus formed with for example sodium hydroxide solution yields the corresponding N'-(w-hydroxylower alkyl)-N-piperazinyl derivatives of Formula I. Further alkylation of the N-piperazinyl compounds thus obtained with an alkylene oxide or alkylene halohydrin yields other N'-substituted piperazinyl compounds of Formula I.

The 9-unsubstituted starting materials used as above are either known or prepared conveniently as illustrated by the following outline of the preparation of 2- trifluoromethyl-lO-anthrone. Phenyl magnesium bromide is reacted with 2-bromo-4-trifluoromethylbenzonitrile to give 2-bromo-4-trifluoromethylbenzophenone. The latter is reduced with for example phosphorus and hydrogen iodide to yield 2-bromo-4-trifluoromethyl-diphenylmethane, which is reacted first with magnesium. then with carbon dioxide to give 2- benzyl-S-trifluoromethylbenzoic acid. Cyclization by acid treatment with for example concentrated sulfuric acid furnishes the Z-trifluoromethyl-lO-anthrone.

The compounds of Formula I when R is lower alkyl or phenyl and especially when Y is trit'luoromethyl are prepared as shown in the following sequence illustrated by way of example for R is methyl and Z is dimethylamino:

CH l 3 f ca m G! O-A-MEX CN c-mt I A-OCH l5 an:

A'N(CH According to the above procedure, the substituted Z-ta-methylbenzyl)-benzonitrile is reacted with a methoxyalkyl magnesium halide as described more fully hereinabove to give the methoxyalkyl imine derivative. The latter is treated with concentrated (48%) hydrobromic acid to simultaneously ring close and cleave the methyl ether linkage. The resulting IO-bromoalkylanthracene is treated with the appropriate amine to give the corresponding lO-aminoalkylanthracenc 50 which is reduced with, preferably, hydrogen and copper chromite catalyst to the 9-alkyl-9,l0-

dihydroanthracene product.

The benzonitrile starting materials used as above are either known or prepared conveniently as illustrated by the following outline of the preparation of 2-( crmethylbenzyl)-5-trifluoromethylbenzonitrile. 2- Bronte-4-trifluoromethylbenzophenone is reacted with a tri-loweralkyl sulfoxonium halide such as trimethylsulfoxonium iodide in a suitable organic solvent for example dimethyl sulfoxide usually in the presence of a strong alkali such as an alkali metal hydride, i.e. sodium or potassium hydride or an alkali metal lower alkoxide such as sodium methylate or ethylate to give l-phenyll-( 2-bromo-4-trifluoromethylphenyl )-ethylene oxide. The latter is reduced with a bimetallic hydride such as lithium aluminum hydride in a suitable nonpolar organic solvent such as ethyl ether or tetrahydorfuran to oz-phenyl-a-(2-brom0-4-trifluoromethylphenyl)- ethanol. This alcohol is then reduced with phosphorus and hydrogen iodide to Z-(a-methylbenzyU-S- trifluoromethyl-bromobenzene which is treated with cuprous cyanide to give the corresponding benzoni- In addition, it will be readily apparent to one skilled in the art that certain compounds of this invention may be present as optical isomers. These isomers are separated by recrystallization of the optically active acid adtrile. Alternatively, this benzonitrile may be hydrolyzed 5 dition salts, for example the d-and l-di-pto the benzoic acid and cyclized with for example sulfutoluoyltartrates of the racemic free base. Alternatively. ric acid to give 9-methyl-2-trifluoromethyl-l0- a precursor in the synthesis of the products of formula anthrone which may be converted to products of this I may be resolved into d-and l-isomers and the sepainvention as described hereinabove. rated isomers reacted further to give the optically ac- Either of the two general procedures described above 10 tive products. for the preparation of compounds of Formula I may be The connotation of the general formulas presented interchanged. For example, 2-bromo-4-trifluoromeherein is to include all isomers, the separated d or 1 opthyldiphenylmethane is converted with cuprous cyatical isomers as well as the d1 mixture and the separated nide to the Z-benzyl-S-trifluoromethylbenzonitrile cis or trans isomers as well as the mixture of these isowhich is then reacted with a methoxyalkyl magnesium l5 mers. halide to give the imine followed by similar reactions as A useful pharmacological indicator of tranquilizing described above to furnish the corresponding 9- activity is the production of ptosis in rats. In this proce unsubstituted-9,lO-dihydroanthracene products. dure rats are examined after oral administration of a Some of the compounds of this invention may be test compound at hourly intervals for a ptotic effect present as cis or trans isomers as well as mixtures of and the incidence of ptosis is recorded as a percentage these isomers. For example, when R in formula I is of the number of test animals. Another test procedure other than hydrogen the geometrical isomers may be for evaluating traquilizing activity is the suppression of represented as follows: rage in mice. A test compound is administered orally to mice preselected for their ability to exhibit rage episodes during footshock and the animals are tested again. The percentage of animals exhibiting protection against rage is recorded.

Antidepressant activity is measured pharmacologically by the ability of a compound to prevent reser pineinduced ptosis in rats or mice. In this procedure a test compound is administered orally to the animals fola! lowed at various time intervals by l mg/kg of reserpine (|.v.) and the test animals are observed 45 minutes The isomers are separated by fractional crystallization thereafter for ptosis prevention. of their acid addition salts from a suitable solvent or The following table 1 sets forth comparative data obmixture of solvents such as, for example, acetone-ether tained by employing the above described test proceor ethanolether. Also, a pure isomer may be obtained dures for selected compounds of this invention and the directly from the reduction of the lO-aminoalkyl anclosest known prior art 10-aminoalkyl-9,l0- thracene. dihydroanthracenes.

TABLE I Compound Oral Dose Rat Ptosis (mg/kg free base) Maximum Production Prevention (CH l -N(CH Us. 2,403,483 B.

CH 3 CH Compound 7 TABLE l-Continued Oral Dose Rat Ptosis (mg/kg free base] Maximum /c Production k Prevention Austria 22311 I l 5.4 11.5 3 10.x 62.5 21.6 751] (CH -N(CH 2 ED,,,,=1 Ll mg/kg D. Cis lsomer H CH ED =l 4.5 mg/kg From the above table it is observed that the prior art compounds A and B are either inactive or demonstrate activity at doses considerably higher than compounds C and D of the invention.

In general the separated l-isomer of a racemic compound of this invention is more active pharmacologically than the corresponding racemic mixture as illustrated in table 2 for tranquilizing activity.

TABLE 2 Oral ED Compound Mouse Rage Suppression (mg/kg free base) dl 6.2 l 3.2 B. Cis lsomer H CH H (CH -N(CH dl 32.] l l().3

As noted hereinabove the compounds of formulas I and ll wherein R is lower alkyl or phenyl have both tranquilizing and antidepressant activity. Thus the compound D in table I has an ED of l4.5 mg/kg in the rat ptosis prevention test (antidepressant activity) and the same compound B (dl-isomer) in table 2 has an ED, of 32.1 mg/kg in the mouse rage suppression test (tranquilizing activity). To demonstrate that compounds of formulas l and II when R is hydrogen do not have antidepressant activity, test results are shown in table 3 for mouse ptosis prevention.

H (CH -N(CH 505F014 mg/kg Thus, although the parent compound A shown in table 3 has no antidepressant activity, the presence of a 9- methyl substituent in compound B incorporates a component of antidepressant activity while retaining the already present tranquilizing activity of the parent compound A.

A further aspect of this invention relates to 9- substituted-IO-aminoalkyl-Q.lO-dihydroanthracenes which are not benzo ring substituted. These com pounds have antidepressant activity with no tranquilizcompound of formula I or IV with carriers according to ing activity. The antidepressant activity is demon accepted pharmaceutical practices. In practice. unit strated in standard pharmacological test procedures doses Of from gto 2. gtered from One employed in characterizing imipramine and amitryptyto four times a day are effective. line at oral dosages in mice and rats approximately Thefollowing examples are not limiting but are illusequivalent to the latter agents. These 9-substittited-l O- trative of compounds of this invention and procedures aminoalkyl-9,lO-dihydroanthracenes are represented for their preparation and will serve to make fully apparby the following general structural formula: ent all of the compounds embraced by the general fornulas given above. Alternatives and modifications of a lo the general procedures set forth herein will be apparent to those skilled in the art.

- EXAMPLE 1 A mixture of l2.7 g. of magnesium and 56.7 g. of 3- 5 methoxypropyl chloride in 300 ml. of ether is refluxed A4 for 1 hour. The resulting mixture is cooled to about l0 C. and a suspension of 34.3 g. of 2-chloro-l0- w anthrone in 250 ml. of ether is added. The reaction 7 mixture is allowed to warm to room temperature and when: stand overnight. Most of the ether is removed and the R represents lower alkyl, such as methyl or ethyl, of residue decomposed with ammonium sulfate in a miniphenyl; and mum .of water plus ice. The mixture is extracted with A and Z are as defined in formula 1 aboveether, the extract evaporated and the residue taken up The compounds of the formula IV are prepared adinto benzene. The benzene is extracted with alkali and vantageously by direct alkylation of an R -substitutedthen evaporated t gi 2 h1 l()-h d -lo- 3 9,l0-dihydroanthracene with a tertiary aminoalkyl halmethoxypropyl)-9, l O-dihydroanthracene. ide, such as dimethylaminopropyl chloride, in an inert A solution of 28.7 g. of the above 9,l0- organic solvent, for example dim ethylsulfoxide or an dihydroanthra ene in 110 ml. of 48% hydrobromic Ethel" Prefhrabl) alkali metal S h 0f the 9,10' acid and 225 ml. of glacial acetic acid is refluxed for 6 dlhydmamhfacehe is employed which is P p for hours. The reaction mixture is then concentrated, diexample from sodium hydride 0T hutyl hlhhmh Ahfifluted with water and madestrongly alkaline. The soluhath/ell, methods analogous to those described the tion is extracted with ether and the dried extract is preparation of compounds of formula I above may be chromatographed on alumina to give 2-chloro-l0-(3- employed t0 obtain compounds of formula IV. Simib ornop opyl)q thrac qe m4 77-78C larly these compounds m y e present as trans Into a solution of 10.0 g. of the above anthracene in mers which are separated by fractionation. Also, a pure 30 f benzene i b bbl d about [2 f di h lcis isomer upon treatment with sodium hydride in diamine t room t m erature, The resulting mixture i methylsulfoxide gives a mixture of cis, trans isomers h d i a pressure b t l on a steam b th for four f which the pure trans isomer is separated. hours, cooled and allowed to stand. The reaction mix- ]h contrast to the Compounds of the fmmulas l and ture is made basic, treated with ether and filtered. The I] wherein R is lower alkyl P y which hat/e both separated, driedether solution is evaporated to give 2- tranquilizing and antidepressant activity, the comh] 3.i h 1 i ]y mb h 'pounds of formula [V which share the structural fead hl id n, 234 235C ture of 9-substituent but lack the benzo ring substituent have antidepressant activity but no tranquilizing activ- A mixture of 2.0 g. of the above free base and 2.0 g.

of red phosphorus in ID ml. of 57% hydroiodic acid is This is Show" in the fOhOwihg table refluxecl for. 24 hours. The reaction mixture is diluted TABLE 4 Compound Oral Dose Rat Ptosis (mg/kg free base) Maximum i Production Prevention A. Cis Isomer H C H 3 H (CH -N(CH The novel compounds of this invention may be ad- 5 with water, filtered, made basic and extracted with ministered orally or parenterally in conventional dosether to give 2ch|oro-lO-(B-dimethylaminopropyl)- age unit forms such as tablets, capsules, injectables or 9,10-dihydroanthracene; hydrochloride salt, m.p. the like, by incorporating the appropriate dose or a 20l203C EXAMPLE 2 A mixture of 18.2 g. of 2-chloro-10-(3-bromopropyl- )anthracene (prepared as in Example 1) and 11.0 g. of N-methylpiperazine in 50 ml. of toluene is refluxed for 24 hours. The reaction mixture is made basic and extracted with ether to give 2-chloro-l0-l3-(N'-rnethyl- N-piperazinyl)propyH-anthracene; hydrochloride salt. m.p. 260C. dec.

A mixture of 2.0 g. of the above free base and 2.0 g. of red phosphorus in 10 ml. of 57% hydroiodic acid is refluxed for 24 hours. The reaction mixture is diluted. filtered and made basic to give 2-chloro-l0-[3(N methyl-N-piperazinyl)-propyl]-9,lO- dihydroanthracene; hydrochloride salt, m.p. 233C. dec.

Similarly. by employing an equivalent amount of dibutylamine instead of N-methylpiperazine in the above sequence. there is obtained 2-chloro-l0-(3- dibutylaminoprt.pyl)-9,lO-dihydroanthracene.

EXAMPLE3 To a solution of 20 g. of 2-bromo-4-trifluoromethylbenzonitrile in 300 ml. of ether is added 29 ml. of a 3M solution of phenylmagnesium bromide in 100 ml. of ether and the resulting mimxture is refluxed for 3 hours, then stirred for 16 hours at room temperature. The dried ether solution is evaporated and the residue treated with excess dilute hydrochloric acid to give the imine which is heated on the steam bath for one hour. This mixture is extracted with ether to give after fractional distillation, 2-bromo-4-trifluoromcthylbenzophenone, m.p. 5253C.

A mixture of 12.5 g. of the above benzophenone and 12.5 g. of red phosphorus in 25 ml. of 57% hydroiodic 7 acid is refluxed and stirred under nitrogen for 24 hours The reaction mixture is diluted with water, filtered and solid washed with ether and water. The ether solution is dried and evaporated to give 2-bromo-4-trifluoromethyldiphenylmethane, b.p. 97-l00C./0.2 mm.

The Grignard reagent prepared from 5.0 g. of the above diphenylmethane and 0.4 g. of magnesium in 50 ml. of tetrahydrofuran is poured into 200 ml. of ether saturated with carbon dioxide at 80C. The reaction mixture is extracted with dilute sodium hydroxide solution, neutralized with dilute acid and concentrated. The residue is taken up in ether, washed with dilute hydrochloric acid, dried and concentrated to give 2- benzyl-trifluoromethylbenzoic acid, m.p. 148-l50C.

A solution of 19.9 g. of the above acid in 58 ml. of concentrated sulfuric acid is stirred at room temperature for three hours, poured into 700 ml. of water and filtered to give Z-trifluoromethyl-10-anthrone, m.p. 148l50C.

A mixture of 8.65 g. of 3-methoxypropyl chloride and 1.9 g. of magnesium in 100 m1. of ether is stirred and refluxed for 2 hours. To this mxture at 10C. is added a suspension of 6.0 g. of 2-trifluoromethyl-10- anthrone in ether. After stirring for 3 hours at 10C., then 16 hours at room temperature, the reaction mixture is poured into ammonium chloride solution and extracted with ether. The extract is evaporated, taken up in benzene, extracted with base, washed with water, dried and evaporated to give Z-trifluoromethyl-lO- hydroxy-10-(3-methoxypropyl)-9.10- dihydroanthracene. The latter, 2.0 g., in 7.5 ml. of 48% hydrobromic acid and 14 ml. of glacial acetic acid is refluxed for six hours. The reaction mixture is evaporated. taken into ether and chromatographed to give Z-trifluoromethyll (H 3-bromopropyl)-anthracene. m.p. 8788C.

The above anthracene (15.0 g.) and 18 g. of dimethylamine in 45 ml. of benzene is heated on the steam bath in a pressure bottle for six hours. The reaction mixture is treated with water and extracted with dilute hydrochloric acid. The acid extract is made basic, extracted with ether and the dried ether extract is evaporated to give 2-trifluoromethyl-10-(3-dimethylaminopropyl)-anthracene, b.p. l55-160C./O.35 mm.

A mixture of 3.8 g. of the above anthracene, 0.6 g. of copper chromite and 15 ml. of decalin is heated at 200C. under 4,000 lbs. hydrogen pressure for three hours to give upon workup the product 2 trifluoromethyll 0-( 3-dimethylaminopropyl)-9, l 0- dihydroanthracene', hydrochloride salt, m.p. 194.5-l96C.

EXAMPLE 4 To a mixture of 0.72 g. of sodium hydride (56% suspension in mineral oil) and 3.7 g. of trimethylsulfoxonium iodide in 25 ml. of dimethylsulfoxide is added 5.0 g. of 2-bromo-4trif1uoromethylbenzophenone (prepared as in Example 3) in 8 ml. of dimethylsulfoxide. The resulting mixture is stirred for 30 minutes at room tem perature then heated at 50-5 5C. for 90 min utes. The reaction mixture is poured into water, extracted with ether, and the extract evaporated to give l-phenyl-1-(Z-bromo-4-trifluoromethylphenyl)- ethylene oxide, m.p. 7778C.

The above oxide (12.7 g.) in 55 ml. of ether is added to 1.0 g. oflithium aluminum hydride in 55 m1. ofether and the mixture is refluxed for 1 hour. Water (2 ml.) 2 added and the reaction mixture is filtered to give a-pht-n; l-a-( 2-bromo-4-trifluoromethylphenyl)-ethanol. The latter (12.5 g.) is refluxed and stirred with 12.5 g. of red phosphorus and 25 ml. of 57% hydroiodic acid for 24 hours. The reaction mixture is filtered to give 2- (a-r'nethylbenzyl)-5-trifluoromethyl-bromobenzene.

A mixture of 2.4 g. of the above bromobenzene, 0.7 g. of cuprous cyanide and 1.5 ml. of dimethylformamide is stirred and refluxed for four hours. The reaction mixture is poured into a solution of 3.1 g. of ferric chloride in 4.5 ml. of water and 0.8 ml. of concentrated hydrochloric acid, extracted with chloroform, waterwashed, dried and distilled to give Z-(a-methylbenzyl) 5trifluoromethylbenzonitrile.

To the Grignard solution formed with 6.2 g. of 3- methoxypropy1 chloride and 1.4 g. of magnesium in 75 ml. of tetrahydrofuran is added 5.0 g. of the above nitrile in 50 ml. of tetrahydrofuran and the mixture is refluxed for 2 hours. The reaction mixture is decomposed with ammonium chloride solution and extracted with ether. The dried ether extract is evaporated to give the methoxypropy1 imine (29 g.) which is refluxed for six hours in ml. of 48% hydrobromic acid and 200 ml. of acetic acid. The reaction mixture is evaporated, extracted with ether and the dried extract chromatographed to give 2-trifluoromethyl-9-methyl-10,(3- bromopropyl)-anthracene.

A mixture of 12.0 g. of the above anthracene and 18 g. of dimethylamine in 60 ml. of dry benzene is heated in a pressure bottle on a steam bath for 5 hours. The reaction mixture is treated with water and extracted with dilute hydrochloric acid. The acid extract is made basic. extracted with ether and the dried extract evaporated to give Z-trifluoromethyl-9-methyl-l0-(3-dimethylaminopropyl)-anthracene, b.p. l65-170C. 0.] mm.; hydrochloride salt, m.p. 263C. (dec.).

The above anthracene (2.0 g.) is reduced with 0.34 g. of copper chromite in 4 ml. of decalin at 200C. and

4,000 lbs. hydrogen for 3 hours to give 2- tri-fluoromethyl-9-methyl-l0-(3- dimethylaminopropyl )-9, l O-dihydroanthracene; hy-

drochloride salt, m.p. l79l81C. This is the cisisomer.

Similarly. reaction of 2-trifluoromethyl-9-methyl-l0- (3 bromopropyl)-anthracene with N-methylpiperazine as described above followed by reduction yields the corresponding 2-trifluoromethyl-9-methyll 3-( N methyl-N-piperazinyl)-propyl]-9,l0- dihydroanthracene.

EXAMPLE A mixture of 12.0 g. of 2-trifluoromethyl-l0-(3- bromopropyl)-anthracene (prepared as in Example 3) and 4.9 g. of N-methylpiperazine in 40 ml. of benzene is heated in a pressure bottle on the steam bath for l2 hours. Water is added to the reaction mixture, made basic and benzene separated which gives 2- trifluoromethyll0-[ 3-(N '-methyl-N-piperazinyl prQpyH-anthracene. b.p. l85-l89C./0.l mm.; hydrochloride salt, mp. 280C. (dec.).

The above anthracene free base (4.6 g.) in ml. of decalin and 0.74 g. of copper chromite are heated at 200C. and 4,000 lbs. hydrogen to give 2- trifluoromethyll 0-[3-( N-methyl-N-piperazinyl propyl1-9,IO-dihydroanthracene; hydrochloride salt, mp. 263C.

Similarly, in the above reaction sequence, reacting an equivalent amount of pyrrolidine or piperidine instead of N-methylpiperazine results in the formation of 2- trifluoromethyll 0-[ 3-( N-pyrrolidinyl)-propyl]-9, l 0- dihydroanthracene and Z-trifluoromethyl-l0-[3-(N- piperidinyl)-propyl}-9,IO-dihydroanthracene, respectively.

EXAMPLE 6 Following the general procedures of Example I, a mixture of 12.7 g. of magnesium and 64.0 g. of 3-methoxy-2-methylpropyl chloride in 300 ml. of ether is treated with 31.2 g. of Z-methyI-lO-anthrone in 250 ml, of ether to give 2-methyl-l0-hydroxy-l0-(3- methoxy-Z-methylpropyl )-9 l O-dihydroanth racene. The latter is similarly dehydrated and hydrolyzed with 48% hydrobromic acid and the bromo compound reacted with dimethylamine to give 2-methyl-l0-(3- dimethylamino-2-methylpropyl)-anthracene. Reduction with red phosphorus and 57% hydroiodic acid yields the product, 2-methyl-l0-(3-dimethylarnino-2- methylpropyl )-9, 1 O-dihydroanthracene.

EXAMPLE 7 Following the procedure outlined in Example 3, 2- trifluoromethyl-l0-(3-bromopropyl)-anthracene l5.0 g.) is treated with excess aqueous ammonia, methylamine or butylamine to give after reduction the products, Z-triflurormethyll 0-( 3-aminopropyl )-9, l 0- dihydroanthracene, 2-trifluoromethyll 0-( 3- methylaminopropyl)-9,IO-dihydroanthracene and 2- trifluoromethyll 0-( 3-butylaminopropyl)-9,l 0- dihydroanthracene, respectively.

EXAMPLE 8 A mixture of 12.0 g. of 2-trifluoromethyl-l0-(3- bromopropylJ-anthracene (prepared as in Example 3) and 8.4 g. of N-(B-acetoxyethyl)-piperazine in ml. of toluene is refluxed for 12 hours to give after workup. 2-trifluoromethyl-10-[3-(N'-B-acetoxyethyl-N- piperazinyl)-propyl]-anthracene which is reduced with copper chromite, hydrogen to yield the product, 2- trifluoromethyll 0-[ 3-( N -B-acetoxyethyl-N- piperazinyl )-propyl ]-9. l 0-dihydroanthracene.

Hydrolysis of the above acetoxyethyl compound furnishes 2-trifluoromethyl-lO-l3-(N'-B-hydroxyethyl-N- piperazin yl )-propyl]-9. l O-dihydroanthracene.

Alkylation ofthe above hydroxyethyl compound with bromohydrin in the presence of potassium carbonate yields 2-trifluoromethyl-l0-[3-(N'-mhydroxyethoxyethyl-N-piperazinyl )-propyl ]-9. l 0- dihydroanthracene.

EXAMPLE 9 A mixture of 10 g. of 2-trifluoromethyl-9-methyl-l0- (3-dimethylaminopropyl)-anthracene (prepared as in Example 4), 15 g. of red phosphorus and 70 ml. of 57% hydroiodic acid solution is refluxed and stirred for 40 minutes. The reaction mixture is poured into water, made basic with sodium hydroxide solution, stirred for 1 hour with excess ether and filtered. The dried filtrate is evaporated in vacuo to give the free base which is a mixture consisting of about of the transand 20% of the cis-isomer of 2-trifluoromethyl-9-methyl-l0-(3- dimethylaminopropyl )-9, l O-dihydroanthracene. Recrystallization of the hydrochloride salt of the mixture from acetone-ethyl acetate yields the pure trans-isomer hydrochloride, m.p. 200-20lC.

EXAMPLE 10 A mixture of [8.5 g. of l'di-p-toluoyltartaric acid and l6.7 g. of cis-2-trifluoromethyl-Q-methyl-10-(3- dimethylaminopropyl)-9,lO-dihydroanthracene (pre pared as in Example 4) in ml. of boiling methanol and 10 ml. of water yields the l-di-p-toluoyltartrate salt, m.p. l67C. (foam), [(11 3.66. The free base liberated from this salt with ammonium hydroxide and ether is converted to the hydrochloride salt of d-cis-2- trifluoromethyl-Q-methyl-10-(3- dimethylaminopropyl)-9,lO-dihydroanthracene, 209-210C., [011 +9.62 (2% ethanol).

The filtrate from the crude l-di-p-toluoyltartrate sald above is treated with ammonium hydroxide and ether to regenerate l3.5 g. of the cis free base. The latter with 15.0 g. of d-di-p-toluoyltartaric acid in 200 ml. of methanol and 20 ml. of water forms the d-di-ptoluoyltartrate salt, [01],, 2.4 (l% ethanol). The liberated free base is converted to the hydrochloride salt of lcis-2trifluoromethyl-9-methyll 0-( 3- dimethylaminopropyl-9,10-dihydroanthracene, m.p. 206-208C., [11],? 9.6(2% ethanol).

EXAMPLE ll To a solution of 7L8 g. of 2-benzyl-5-trii'luoromethylbenzonitrile (prepared from 2-bromo-4- trifluoromethyldiphenylmethane by reaction with cuprous cyanide) in 100 ml. of ether is added gradually 183 ml. of 3M methyl magnesium bromide in ether. The reaction mixture is refluxed with stirring for 6 hours, decomposed with aqueous ammonium chloride, extracted with ether and evaporated. The residue is taken up in 250 ml. each of 48% hydrobromic acid solution and acetic acid. refluxed for 18 hours, evaporated and extracted with chloroform. The filtered extract is evaporated. the residue is dissolved in methanol and the solvent removed to give Z-trifluoromethyl-IO- methylanthracene, m.p. 98-l00C.

A mixture of the above prepared anthracene (33.2 g.) and 34.2 g. of N bromosuccinimide in 300 ml. of carbon tetrachloride. catalyzed by 0.34 g. of benzoyl peroxide, is refluxed and stirred for two hours. The hot reaction mixture is filtered and cooled to precipitate 2-trifluoromethyl-1U-bromomethylanthracene.

To 5.2 g. of 57% sodium hydride in lOO ml. of dimethylsulfoxide at 50C. is added slowly a solution of 19.8 g. ofdiethylmalonate in dimethylsulfoxide and the mixture is heated at 75C. for 45 minutes. A slurry of 36.5 g. of Z'trifluoromethyI-IO- bromomethylanthracene in dimethylsulfoxide is added and the resulting mixture is heated at 75C. for l hour. The reaction mixture is quenched with water and extracted with ether to give diethyl (3-trifluoromethyllO-anthracenyl)-methylmalonate. The latter (50.7 g.) is hydrolyzed with 4i g. of potassium hydroxide in 200 ml. of 60% aqueous ethanol to the free malonic acid which is heated at l85"-200C. to obtain 2- trifluoromethylanthracenel O-propionic acid.

A mixture of 32.7 g. of the above prepared propionic acid and 48 g. of red phosphorus in l60 ml. of 57% hydroiodic acid and 75 ml. of acetic acid is refluxed and stirred for three hours. The reaction mixture is diluted with water, extracted with chloroform, washed with water and evaporated to yield 2-trifluoromethyl-9,l0- dihydroanthracenel O-propionic acid, m .p.

l53-l55C.

A solution of 8.0 g. of 2-trifluoromethyl-9.l0- dihydroanthracene-lO-propionic acid and 3.0 g. of d-aphenethylamine in 45 ml. of ethanol is clouded with 50 ml. of water while boiling to give the d-aphenethylamine salt, m.p. l79l8lC., [011 3.2 (l% ethanol). This salt is acidified with hydrochloric acid, extracted with ether and the dried extract evaporated to give I -2-trifluoromethyl-9. l dihydroanthracene-lO-propionic acid. The latter is refluxed with 5 ml. of thionyl chloride for 2 hours and the resulting acid chloride dissolved in ml. of benzene is saturated with dimethylamine to yield the dimethylamide. The amide (2.2 g.) in ether is added to l,l g. of lithium aluminum hydride in ether, refluxed for one hour and worked up to give d-2-trifluoromethyl-l0-(3- dimethylaminopropyl )-9, l O-dihydroanthracene; hydrochloride salt, m.p. 20l202C.. [01],, +4.92 (1% ethanol).

The filtrate from the crude d-a-phenethylamine salt above is evaporated, acidified and extracted with ether to regenerate 2-trifluoromethyl-9,l0- dihydroanthracene-l0propionic acid. The latter (6.2 g.) and 2.4 g. ofl-a-phenethylamine dissolved in ml. of ethanol is clouded while boiling with 50 ml. of water to give the l-a-phenethylamine salt, m.p. l77-l79C.. [n:],, +3.46". This salt is acidified to liberate d-2- trifluoromethyl-Q,IO-dihydroanthracene-lO-propionic acid which is treated as above with thionyl chloride. the acid chloride reacted with dimethylamine and the amide reduced with lithium aluminum hydride to yield l-2-trifluoromethyl-l0(3-dimethylaminopropyl)-9.l0- dihydroanthracene; hydrochloride salt. m.p. 200-202C.. [a],, =5.73 l% ethanol).

EXAMPLE 12 Following the general procedure of Example 3. I82 g. of 2-bromo-4-methylthiobenzonitrile (obtained from 4-methylthiobenzonitrile) and 29 ml. of 3M phenylmagnesium bromide in ether solution are reacted to give 2-bromo-4-methylthiobenzophenone. A mixture of the latter and red phosphorus in 57% hydroiodic acid is refluxed and stirred under nitrogen for 24 hours to give 2-bromo-4-methylthiodiphenylmethane. The Grignard reagent prepared from this diphenylmethane in tetrahydrofuran is poured into ether saturated with carbon dioxide at C. Workup yields 2-benzyl5- methylthiobenzoic acid. A solution of the acid in concentrated sulfuric acid is stirred at room temperature to give the ring-closed product, Z-methylthio-lO- anthrone.

To the Grignard reagent prepared from 8.65 g. of 3- methoxypropyl chloride in ether is added a suspension of 5.5 g. of Z-methylthio-lO-anthrone in ether. After stirring for 3 hours at l0C. and 18 hours at room temperature, the reaction mixture is decomposed and worked up to give 2-methylthio-l0-hydroxy-lO-(3- methoxypropyl)-9,lO-dihydroanthracene. The latter is refluxed in 48% hydrobromic acid and glacial acetic acid to give 2-methylthio-l0-(3-bromopropyl)- anthracene.

The above anthracene (13.7 g.) and 18 g. of dimethylamine in benzene is heated on the steam bath in a pressure bottle for 6 hours to give upon workup 2- methylthio-l0-(3-dimethylaminopropyl)-anthracene which is hydrogenated in the presence of copper chromite to yield 2-methylthio-10-( 3- dimethylaminopropyU-Q,lO-dihydroanthracene.

Similarly, by employing 2-bromo-4-methylsulfonylbenzonitrile (obtained from the 4-methylthio derivative by oxidation with chromic anhydride in sulfuric acid) in the above described reaction sequence there is obtained as a final product, 2-methylsulfonyl-l0-(3- dimethylaminopropyU-Q,lO-dihydroanthracene.

EXAMPLE l3 Following the general procedure of Example 3, l6.8 g. of 3-br0mo-4-cyanoN.N-dimethylbenzenesulfonamide (obtained from 4-cyano-N,N-dimethylbenzenesulfonamide) in ether is reacted with 29 ml. of 3M phenylmagnesium bromide in ether and the mixture worked up to give 2-bromo-4-(N,N-dimethylsulfamyl)- benzophenone which is reduced with red phosphorus and hydroiodic acid to the corresponding diphenylmethane. The Grignard reagent prepared from this diphenylmethane is reacted with carbon dioxide with cooling to give 2-benzyl-5-(N,N-dimethylsulfamyl)- benzoic acid. Ring closure is effected via concentrated sulfuric acid to yield 2-(N,N-dimethylsulfamyl)-l0- anthrone.

The Grignard reagent prepared from 8.65 g. of 3- methoxypropyl chloride is reacted with 5.0 g. of the above-prepared anthrone to give 2-(N,N- dimethylsulfamyh-lO-hydroxy-l0-(3-methoxypropyl)- 9,l0-dihydroanthracene. The latter is refluxed in 48% hydrobromic acid and glacial acetic acid to give 2- (N,N-dimethylsulfamyl)-l0-(3-bromopropyl)- anthracene.

The above anthracene (12.6 g.) and l8 g. of dimethylamine in benzene is heated on the steam bath in a pressure bottle for 6 hours to give upon workup 2- 17 (N.N dimethylsulfamyl)-l-(3-dimethylaminopropyl)- anthracene which is hydrogenated in the presence of copper chromite to yield 2-(N,N-dimethylsulfamyl)- l0-(3-dimethylaminopropyl)-9,IO-dihydroanthracene.

EXAMPLE 14 To a solution of 32.9 g. of 2-bromo-4-trifluoromethylbenzophenone in 400 ml. of ether is added one equivalent of ethylmagnesium bromide in ether and the resulting mixture is refluxed for 4 hours. Treatment with aqueous acid gives a-phenyl-a-(2-bromo-4-trifluoromethylphenyl)-propanol. The latter (13.0 g.) is refluxed and stirred with 12.5 g. of red phosphorus and 25 ml. of 57% hydroiodic acid for 24 hours to yield 2 (a-ethylbenzyl)-5-trifluoromethylbromobenzene.

A mixture of 2.5 g. of the above bromobenzene, 0.7 g. of cuprous cyanide and L5 ml. of dimethylformamide is stirred and refluxed for 4 hours. The reaction mixture is poured into a solution of 3.] g. of feric chloride in 4.5 ml. of water and 0.8 ml. of concentrated hydrochloric acid, extracted with chloroform, waterwashed, dried and distilled to give 2-(a-ethylbenzyl)-5- trifluoromethylbenzonitrile.

To the Grignard reagent formed with 6.2 g. of 3- methoxypropyl chloride in 75 ml. of tetrahydrofuran is added 5.2 g. of the above nitrile and the mixture is refluxed for two hours. The decomposed reaction mixture yields the methoxypropyl imine which is refluxed for 6 hours in 100 ml. of 48% hydrobromic acid and 200 ml. of acetic acid. The reaction mixture is evaporated, extracted with ether and the dried extract chromatographed to give 2-trifluoromethyl-9-ethyl-10-(3- bromopropyl )-anthracene.

A mixture of I25 g. of the above anthracene and 18 g. of dimethylamine in 60 ml. of dry benzene is heated in a pressure bottle on a steam bath for five hours. The reaction mixture is heated with water and extracted with dilute hydrochloric acid. The acid extract is made basic and further worked up to give Z-trifluoromethyl- 9-ethyl-l0-(3-dirnethylaminopropyl)-anthracene. The latter (2.8 g.) is reduced with 0.34 g. of copper chromite in 4 ml. of decalin at 200C. and 4,000 lbs. hydrogen to yield 2-trifluoromethyl-9-ethyl-l 0-( 3- dimethylaminopropyl)-9, lO-dihydroanthracene.

Similarly by commencing the above sequence of reactions employing phenylmagnesium bromide instead of ethylmagnesium bromide there is obtained the corresponding Z-trifluoromethyl-9-phenyll 0-( 3-dimethylaminopropyl)-9,IO-dihydroanthracene.

EXAMPLE l5 To a suspension of 2.1 g. of 56% sodium hydride in 45 ml. of dimethylsulfoxide is added gradually, with stirring, 7.5 g. of 9-methyl-9,lO-dihydroanthracene and the mixture heated at 70C. for 2 hours. A solution of 7.5 g. of 3-dimethylaminopropyl chloride in 30 ml. of dimethylsulfoxide is added and heating is continued for 3 hours. The reaction mixture is quenched with water, extracted with ether and the ether extracted with dilute hydrochloric acid. The acid extract is made basic to give the liberated base, 9-methyll 0-( 3- dimethylaminopropyl)-9,lO-dihydroanthracene; hydrochloride salt. m.p. 2l 3-216C.

EXAMPLE 16 To a solution of 24.8 g. of 9-methyl-9,l0- dihydroanthracene in 300 ml. of ether is added over l5 minutes 96 ml. of 15% butyl lithium in hexane and the resulting mixture is stirred at room temperature for 2 hours. After adding 24.6 g. of 3-dimethylaminopropyl chloride, the mixture is stirred and refluxed for three hours and allowed to stand overnight. The reaction mixture is extracted with dilute hydrochloric acid. made basic, extracted with ether and distilled to give the free base, b.p. l60C./0.5 mm. The latter is fractionated and the first fraction collected at b.p. l35-l 39C./0. l 5 mm. is cis-Q-methyll 0-( 3- dimethylaminopropyl)-9.IO-dihydroanthracene; hydrochloride salt, m.p. 2l72l8C.

The second fraction obtained from above (4.5 g.) is heated about 1 hour at C. with 0.81 g. of 57% sodium hydride in 40 ml. of dimethylsulfoxide. The reaction mixture is quenched in water, extracted with ether, dried and evaporated. The residual free base is converted to a hexamate salt in acetone and recrystallized from acetonitrile to give trans-9-methyl-l0-(3- dimethylaminopropyl)-9,IO-dihydroanthracene hexamate, m.p. l69-l7lC.

What we claim is:

1. A chemical compound of the structural formula:

i i Y f2 CH i a 7 A-Z in which:

R, is lower alkyl or phenyl; A is an alkylene chain of 2 to 4 carbon atoms; and Z is N-pyrrolidinyl, or N-piperidinyl; each of said lower alkyl or alkoxy moieties having from 1 to 4 carbon atoms. or its nontoxic, pharmaceutically acceptable, acid addition salt.

l l 4 l 

1. A CHEMICAL COMPOUND OF THE STRUCTURAL FORMULA:
 2. A chemical compound in accordance with claim 1 in which R is hydrogen and Y is 2-trifluoromethyl.
 3. A chemical compound in accordance with claim 2 in which A is propylene.
 4. A chemical compound of the structural formula: 